TRASTUZUMAB DUOCARMAZINE FOR DUMMIES

The phosphorylated HER3 offers docking web-sites for p85 subunit of PI3K. The fully activated PI3K complicated is generated by binding of p110 subunit of PI3K to p85 which is able to create PIP3 by way of phosphorylating the PIP2. AKT binds to PIP3 and it is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at each threonine and serin phosp